Sahin Naqvi, Ph.D.
Sahin Naqvi, Ph.D. Assistant Professor of Pediatrics Boston Children’s Hospital Linkedin Tuning SOX10 Dosage in Stem Cell Therapies for Hirschsprung Disease Hirschsprung disease is a life-threatening childhood condition in which neurons that control movement of waste through the intestine fail to develop, leading to severe constipation, swelling, and infections. Currently, Hirschsprung is treated by removing […]
Maria Gutierrez-Arcelus, Ph.D. – 2025
Maria Gutierrez-Arcelus, Ph.D. Assistant Professor of Pediatrics Boston Children’s Hospital Linkedin Globe Twitter B Cell-mediated Genetic Mechanisms in Lupus Systemic lupus erythematosus (SLE) is an illness where the body’s immune system attacks healthy tissues, often causing harm to the kidneys, joints, and other organs. SLE can begin in childhood or the teenage years, particularly in […]
Sichen Shao, Ph.D. – 2018
Sichen Shao, Ph.D. Assistant Professor Department of Cell Biology Harvard Medical School Linkedin Globe Twitter Activation of Nonsense-mediated Decay in Genetic Diseases and Childhood Development Mutations that introduce a premature termination codon (PTC) into protein-coding transcripts cause over 10% of congenital diseases. Nonsense-mediated decay (NMD) is a dedicated cellular pathway that degrades these mRNAs […]
Amy Lee, Ph.D. – 2017
Amy Lee, Ph.D. Assistant Professor of Biology Department of Biology Brandeis University Linkedin Globe Twitter Regulation of mRNA Translation Initiation in Development Human development requires exquisite spatial and temporal control of the proteins that are expressed in a cell. Translation initiation factors are key players in protein synthesis, and although alterations to these factors […]
James Patrick Noonan, Ph.D. – 2016
James Patrick Noonan, Ph.D. Professor Yale University Linkedin Globe Twitter Discovering Gene Regulatory Networks in Early Human Brain Development that Contribute to Autism Spectrum Disorder Autism spectrum disorder (ASD) is a disorder of brain development with onset early in life, characterized by impairments in social communication and restricted interests and/or repetitive behaviors. The biological pathways […]